Oil dispersible upconverting nanoparticles

Oil dispersible upconverting nanoparticles

Exc. Wavelength: 975 nm

Crystal formula: NaYREF4, RE:Yb, Er, Tm, Gd, Mn, Lu

Morphology: nanosized spheres

Diameter: 25 nm

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This series of products contains oil dispersible NaYREF4 (RE:Yb, Er, Tm, Gd, Mn, Lu) UCNs with optimal excitation wavelength at 975 nm. The sensitizer is Yb3+, and the activator is Er3+ or Tm3+. The doping concentrations are optimized, leading to strong upconverted emissions at specific wavelengths. The size of UCNs can be customized based on user’s need. The UCNs are of high quantum efficiency and very photostable. After proper surface modification and functionalization, the products can be used for fluorescence imaging, biodetection, photodynamic therapy and photoactivation of anti-cancer drugs and biomolecules.

 

 

Upconverting nanoparticles (UCNs) are a novel group of fluorophores which are steadily gaining popularity in the scientific community. The upconversion luminescence arises from a phenomenon whereby light of low energy, usually in the NIR region, is converted to light of higher energy in the shorter wavelength range. Because the mechanism of upconversion fluorescence involves emitting higher energy photons after sequential discrete absorption of two or more lower-energy photons, it is more efficient than conventional simultaneous two-photon absorption, with no requirement for coherent light sources and higher excitation energies. Thus, this permits the use of inexpensive and readily available continuous wave (CW) laser diode.

Using a NIR excitation source prevents auto- fluorescence from biological samples used in analysis. UCNs are also highly photostable and thus suitable for long-term imaging applications. UCNs have been used in a wide range of applications including but not limited to in vitro imaging, in vivo imaging, diagnostic assays, immunohistochemistry, FRET, microarrays, photodynamic therapy and photoactivation.

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